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脳腫瘍の病態解析

当教室が専門とする脳腫瘍病理診断にフィードバックするため、悪性グリオーマや悪性髄膜腫について幹細胞、治療法、発生メカニズムなど様々な角度から研究を行っています。

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    1. Tabu, K., Kimura, T., Sasai, K., Wang, L., Bizen, N., Nishihara, H., Taga, T., Tanaka, S. Analysis of an alternative human CD133 promoter reveals the implication of Ras/ERK pathway in tumor stem-like hallmarks. Mol. Cancer, 9, 39, 2010. (IF=5.130)

    2. Kanno, H., Nishihara, H., Wang, L., Yuzawa, S., Kobayashi, H., Tsuda, M., Kimura, .T, Tanino, M., Terasaka S., and Tanaka, S. Expression of CD163 prevents apoptosis through the production of granulocyte colony-stimulating factor in meningioma. Neuro Oncol., 15, 853-864, 2013. (IF=6.180)

    3. Kohsaka, S., Takahashi, K., Wang, L., Tanino, M., Kimura, T., Nishihara, H., and Tanaka, S. Inhibition of GSH synthesis potentiates temozolomide-induced bystander effect in glioblastoma. Cancer Lett., 331, 68-75, 2013.

    4. Kato, Y., Nishihara, H., Yuzawa, S., Mohri, H., Kanno, H., Hatanaka, Y., Kimura, T., Tanino, M., and Tanaka, S. Immunohistochemical molecular expression profile of metastatic brain tumor for potent personalized medicine. Brain Tumor Pathol., 30, 167-174, 2013.

    5. Kohsaka, S. and Tanaka, S. Chemotherapeutic Agent for Glioma. “Clinical management and evolving novel therapeutic strategies for patients with brain tumors” INTECH 2013.

    6. Mahabir, R., Tanino, M., Elmansuri, A., Wang, L., Kimura, T., Itoh, T., Ohba, Y., Nishihara, H., Shirato, H., Tsuda, M., Tanaka, S. Sustained elevation of Snail promotes glial-mesenchymal transition after irradiation in malignant glioma.
      Neuro Oncol.       5, 671-685, 2014.

    7. Kohsaka, S., Hinohara, K., Wang, L., Nishimura, T., Urushido, M., Yachi, K., Tsuda, M., Tanino, M., Kimura, T., Nishihara, H., Gotoh, N., Tanaka, S. Epiregulin enhances tumorigenicity by activating the ERK/MAPK pathway in glioblastoma.
      Neuro Oncol      ., 16, 960-970, 2014

    8. Miyazaki, M., Nishihara, H., Terasaka, S., Kobayashi, H., Yamaguchi, S., Ito, T., Kamoshima, Y., Fujimoto, S., Kaneko, S., Katoh, M., Ishii, N., Mohri, H., Tanino, M., Kimura, T., Tanaka, S. Immunohistochemical evaluation of O(6) -methylguanine DNA methyltransferase (MGMT) expression in 117 cases of glioblastoma.
      Neuropathol.      , 34, 268-276, 2014

 

 

 

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